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Glutathione

The body’s main antioxidant, discussed for liver support.

StatusFood supplement (oral); injected use not approved for these purposes (EU/UK/US)
How well studied in peopleTested in clinical trials
Experts quoted3 experts

iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. Glutathione is sold as an oral food supplement. We found no EU, UK or US approval of injected glutathione for wellness, fertility or skin uses.

What experts say about dosing

4 statements from 2 people. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.

Nicholas TrigiliHuman performance specialist and coach; fitness YouTuber

Male fertility protocol

Dose
“200 to 400 to even 600 milligrams … around 400 milligrams”
How often
“Two to three times per week minimum … two times a week”
How taken
“injectable only”

“So let's talk about the framework and the dosing with glutathione. Really simple 200 to 400 to even 600 milligrams injectable only. No tablets, no capsules, no troies, nothing. Two to three times per week minimum. Most men respond really well around 400 milligrams two times a week. […] if you drink, you smoke a lot, or you live a really stress intense life, you're going to need probably 800 milligrams a week.”

Watch at 6:45The only 4 Peptides You Need to Recover Fertility in 2026 (Even on TRT) (Nicholas Trigili) · 28 Jan 2026

Context: Part of a protocol to support sperm quality. “troies” is how the captions render “troches”. The cut removes a half-sentence that contradicts itself in the captions.

IV versus subq injections

Dose
“IV: 600 all the way up to 2,000 milligrams per session … subq: 100 to 300 milligrams”
How often
“IV once or twice a week … subq per day, or three, four, five times a week”
How taken
“IV or subq in the abdominal wall”

“When you're getting an IV of glutathione, it typically runs anywhere between 600 all the way up to 2,000 milligrams per session. Typically, it's once or twice a week. […] Now, if you'd rather skip the IV entirely, you have subq injections. Those are more practical and more consistent, easier to do. Typical dose, I would run a glutathione anywhere between 100 to 300 milligrams per day injected subq in the abdominal wall. […] Now, some people run it three, four, five times a week instead of daily, which still is going to maintain your levels just fine.”

Watch at 14:13I’m 39. Here’s Every Peptide I’ve Run So Far in 2026 (Revealing My Protocols) (Nicholas Trigili) · 24 Sep 2026

Context: He says he ran glutathione “periodically throughout the year” and frames it as liver support for men on TRT. The first cut removes a remark on liposomal oral glutathione; the second removes a short aside. These figures differ from his January 2026 statement (above). He says all the peptides in this video were taken alongside the testosterone and HGH he runs all year. He says in his videos that he is not a doctor.

Vigorous SteveBodybuilding coach and YouTuber (VigorousSteve)

Own use: route and injection volume

Dose
“600 milligrams”
How often
“three times a week”
How taken
“intramuscularly”

“uh 600 milligrams injected with glutathione three times a week intramuscularly because the injection volume is a little bit higher. Subq 600 milligrams is for most people like 3 cc's 4 cc's and that's quite a bit and it burns more if you put it subq compared to intramuscular”

Watch at 16:30Injectable SLU, AI Dosing Protocol, Glutathione & NAD+, GH & Insulin Sensitivity, Bioregulator Scam? (VigorousSteve Q&A, 14 Feb 2026) · 14 Feb 2026

Context: Said in a solo Q&A livestream while describing his own antioxidant intake.

Own use: injections

Dose
“600 milligrams”
How often
“three times a week”
How taken
“intramuscularly”

“So I, I just got sick of it. I just inject my glutathione intramuscularly three times a week 600 milligrams and NAD plus 20 milligrams subq or uh 40 milligrams split bilaterally as part of my interworkout protocol”

Watch at 50:44Nebido For Traveling, Skin-Friendly PEDs, GH Carpal Tunnel, Freeze Peptides, NAD+ Vs. NMN… (VigorousSteve Q&A, 28 Feb 2026) · 28 Feb 2026

Context: Explaining why he stopped going to IV clinics; said in a solo Q&A livestream.

What experts say about safety

1 statement from 1 person about risks and how strong the evidence is.

Derek (More Plates More Dates)Fitness educator; founder of More Plates More Dates

Oral glutathione and NAC (own use)

“so um n-acetyl-l-cysteine instead of glutathione, even though oral glutathione seems to actually work, despite a lot of claims online that seem to think that it's not orally bioavailable […] so i used to inject the glutathione though, but um i don't know, there's a lot of clinical data supporting that n-acetyl cysteine is as good or better”

Watch at 26:17Every Single Health Supplement I Currently Take (More Plates More Dates) · 2 Nov 2020

Context: Describing the supplements he takes. The cut removes a remark about skin whitening. He says he now uses NAC instead of glutathione.

Go deeper

What the research used

Context, not a dosing guide. These studies tested oral glutathione in healthy adults or intravenous glutathione in Parkinson’s disease. They are not a guide to injecting it for other purposes.

Human studies

StudyStudied inWhat the study usedWhat it found
Richie et al., 2015, Eur J NutrPubMed 2479175254 healthy non-smoking adultsOral 250 or 1,000 mg/day for 6 monthsBody glutathione stores rose, most with the higher dose
Hauser et al., 2009, Mov DisordPubMed 1923002921 people with Parkinson’s disease (pilot)IV 1,400 mg three times a week for 4 weeksWell tolerated; no significant difference in symptom scores vs placebo
Sechi et al., 1996, Prog Neuropsychopharmacol Biol PsychiatryPubMed 89388179 people with early, untreated Parkinson’s disease (open label)IV 600 mg twice daily for 30 daysAuthors reported symptom improvement; no control group
What we don’t know yet
  • No trial of injected glutathione for fertility, wellness or skin.
  • Vigorous Steve notes possible pro-oxidant effects at the injection site; see his quote on the NAD+ page.
  • Grey-market products are unregulated, so identity, purity and dose accuracy vary.
Common questions

Does oral glutathione work?

In a 6-month trial, oral glutathione raised body stores in healthy adults. Nicholas Trigili says “injectable only”; Derek says oral glutathione “seems to actually work” for him. These are their views.

Why do some quotes say intramuscular?

Vigorous Steve says he injects 600 mg into the muscle because the volume is large and it “burns more” under the skin. That is his experience, not trial evidence.

Is IV glutathione used in medicine?

It has been tested in small Parkinson’s disease trials, with mixed results.

Why does the protocol section only contain quotes?

We do not write our own dose ranges. The protocol cards show, word for word, what named people have publicly said, with their caveats and a link to the source.

About this page

Word-for-word statements about injected glutathione, each with a link to the source. The oral and intravenous research is listed separately as context.

Also known as
GSH; γ-L-glutamyl-L-cysteinylglycine
Type
Naturally occurring antioxidant tripeptide
Last updated
11 Oct 2026

Last reviewed 11 Oct 2026 · Compiled by the Peptide Dosing editorial team · How we check quotes