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Immune support

KPV

A tiny anti-inflammatory peptide discussed for gut and skin.

StatusNot approved (EU/UK/US)
How well studied in peopleAnimal & lab only
Experts quoted3 experts

iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. KPV is not an approved medicine in the EU, UK or US. Products sold online are research chemicals.

What experts say about dosing

1 statement from 1 person. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.

Nicholas TrigiliHuman performance specialist and coach; fitness YouTuber

Gut stack

Dose
“500 to 1,000 micrograms”
How often
“daily”
How long
“cycle off after 8 to 10 weeks”
When
“add this in weeks 3 to 4”

“Next up is KPV. KPV is going to target the gut inflammation at the immune level. Now, if you're dealing with severe bloating, IBS-like symptoms, eczema, or food tolerances, this shuts down that inflammatory cascade. You're going to add this in weeks 3 to 4. 500 to 1,000 micrograms daily. You're going to cycle off after 8 to 10 weeks once the inflammation normalizes.”

Watch at 5:51On TRT? Copy this Peptide Stack to Heal Your Gut 10x Faster in 2026 (Beginners Guide) (Nicholas Trigili) · 30 Mar 2026

Context: Part of a gut stack he describes for men on TRT. He does not state the route for KPV in this passage. He says in his videos that he is not a doctor.

What experts say about safety

2 statements from 2 people about risks and how strong the evidence is.

Ben GreenfieldFitness and longevity author; host of Ben Greenfield Life

Timing around meals

“Proper timing, especially around meals, is crucial for peptides like GHK-Cu, KPV, and TB4. Consuming high-protein meals can reduce the effectiveness of most peptides, so scheduling their use strategically ensures optimal absorption and results.”

Read the sourceBen’s Peptide Stack for Recovery, Explosive Gains, & Ageless Vitality (bengreenfieldlife.com) · 17 Sep 2024

Context: General statement; no KPV dose is given in the article.

Dr Kent HoltorfPhysician; host of the Peptides and Longevity podcast (Big Doc Energy)

What it is

“now kpv is a tiny tripeptide fraction of alpha mesite stimulating hormone. It has more anti-inflammatory effects actually than the whole peptide, but it actually does not stimulate, um, the banocy, so you don't get the darkening of the skin, which is good, plus it's small so it can absorb orally, can cross the blood bra barrier”

Watch at 26:55Peptides 101 (Peptides and Longevity podcast / Big Doc Energy, Dr Kent Holtorf) · 5 Feb 2025

Context: Captions: “alpha mesite” is alpha-melanocyte, “banocy” melanocytes, “blood bra barrier” blood-brain barrier. Oral absorption in people has not been shown in trials; the oral data we found are in mice.

Go deeper

What the research used

Context, not a dosing guide. The KPV studies we could verify are in cells and mice with colitis, with KPV given in drinking water or nanoparticles. No human trial was found, so none of this establishes a dose.

Animal and cell studies

StudyStudied inWhat the study usedWhat it found
Dalmasso et al., 2008, GastroenterologyPubMed 18061177Human gut cells; mice with chemically induced colitisKPV in drinking waterLess intestinal inflammation; uptake via the PepT1 transporter
Xiao et al., 2017, Mol TherPubMed 28143741Mice with ulcerative colitisOral KPV in targeted nanoparticlesReduced colitis
What we don’t know yet
  • No human trials found.
  • Animal studies gave KPV orally, not by injection.
  • Grey-market products are unregulated, so identity, purity and dose accuracy vary.
Common questions

Can KPV be taken orally?

Dr Kent Holtorf says it can be absorbed orally. The oral evidence we found is in mice only.

Does KPV darken the skin like melanotan?

Dr Kent Holtorf says it does not stimulate the pigment cells. We found no human study testing this.

Why does the protocol section only contain quotes?

We do not write our own dose ranges. The protocol cards show, word for word, what named people have publicly said, with their caveats and a link to the source.

About this page

Word-for-word statements about KPV, a three-amino-acid fragment of α-MSH, each with a link to the source. The animal research is listed separately as context.

Also known as
Lys-Pro-Val; α-MSH(11-13)
Type
Synthetic tripeptide (fragment of α-melanocyte-stimulating hormone)
Last updated
11 Oct 2026

Last reviewed 11 Oct 2026 · Compiled by the Peptide Dosing editorial team · How we check quotes