A very short peptide discussed for brain health and sleep.
StatusNot approved (EU/UK/US)
How well studied in peopleAnimal & lab only
Experts quotedNTVSAB3 experts
iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. Pinealon is not an approved medicine in the EU, UK or US. Products sold online are research chemicals.
What experts say about dosing
2 statements from 2 people. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.
AB
Dr Abud BakriInternal medicine physician; guest on Huberman Lab
What people take by mouth
Dose
“anywhere between half a milligram, up to three milligrams”
How taken
“Orally”
“Orally, people will take anywhere between half a milligram, up to three milligrams, is where people settle in. The Kavinson ones that come from Russia are 200 micrograms.”
Context: Answering Andrew Huberman’s question “Do you know the dosages? Not that we’re recommending it”. He describes what people take, not his own protocol. He says earlier that people take it “In the morning. Or at night”.
NT
Nicholas TrigiliHuman performance specialist and coach; fitness YouTuber
Dose and cycle after epitalon
Dose
“8 to 10 mg”
How often
“a day”
How long
“a 20-day cycle … 21 days”
Break
“two to three times a year”
“So, the dosing for this peptide typically runs between 8 to 10 mg a day over a 20-day cycle. I like to do 21 days, so 7 14 21, so it's 3 weeks, two to three times a year. Now, most people run this right after finishing a epitalon cycle. You can run them parallel to each other simultaneously.”
Watch at 9:43I ran EPITALON so you don't have to, here are my honest results (Nicholas Trigili) · 17 Jul 2026
Context: “This peptide” is Pinealon (captioned “Pinelon”), introduced just before as the peptide that “pairs directly” with epitalon. He says in his videos that he is not a doctor.
What experts say about safety
2 statements from 2 people about risks and how strong the evidence is.
VS
Vigorous SteveBodybuilding coach and YouTuber (VigorousSteve)
On bioregulator evidence in general
“and with bio regulators, all I've heard is that yeah, it's great, it's great, it's great from the people who sell it, and then I look at the scientific evidence and I'm like, maybe in a decade.”
Watch at 23:06Injectable SLU, AI Dosing Protocol, Glutathione & NAD+, GH & Insulin Sensitivity, Bioregulator Scam? (VigorousSteve Q&A, 14 Feb 2026) · 14 Feb 2026
Context: Said about Khavinson-type “bioregulator” peptides in general (he had just discussed Cartalax). He does not name pinealon here.
NT
Nicholas TrigiliHuman performance specialist and coach; fitness YouTuber
Own use alongside epitalon
“Now, running alongside that, you can run Pinelon. It works directly on your brain tissue. […] I run both together simultaneously once or twice a year.”
Watch at 13:11I’m 39. Here's everything I'm taking to Beat Aging (Full Stack Breakdown) (Nicholas Trigili) · 20 Jul 2026
Context: “That” is epitalon. The cut removes his description of effects and sleep tracking. No dose given in this video.
Go deeper
What the research used
Context, not a dosing guide. Research on pinealon (the EDR peptide) is mostly cell and animal work from Professor Khavinson’s group. None of it establishes a human dose.
Reviews
Khavinson et al., 2020, Molecules. PubMed 33396470. Review of the EDR peptide by the group that developed it; summarises cell and animal studies and limited observations in older people.
What we don’t know yet
Research comes almost entirely from the group that developed it.
No randomised controlled trial in people found.
Grey-market products are unregulated, so identity, purity and dose accuracy vary.
Common questions
Is pinealon the same as epitalon?
No. Both come from the same Russian research group. Epitalon has four amino acids; pinealon has three (Glu-Asp-Arg).
Why does the protocol section only contain quotes?
We do not write our own dose ranges. The protocol cards show, word for word, what named people have publicly said, with their caveats and a link to the source.
About this page
Word-for-word statements about pinealon, a short Russian “bioregulator” peptide, each with a link to the source. The limited research is listed separately as context.