An oral pill (not a peptide) that raises growth hormone; known for hunger.
iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. MK-677 is not an approved medicine in the EU, UK or US and is on the World Anti-Doping Agency prohibited list. Products sold online are research chemicals.
5 statements from 3 people. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.
“If I had to compare 25 mg of MK-677 to something I would compare the results to 2 iu’s of high quality generic GH, or a few daily 100 mcg injections of GHRP-6 coupled with concurrent 100 mcg injections of Modified GRF (1-29).”
Context: From the “My MK-677 Review” section, where he says “I have used MK-677 a few times over the past couple years now.” A comparison of effects, not a recommendation.
“Based on the study, if fat loss and the anti-aging/healing benefits of HGH is all that is sought after by the user, a 10 mg dose would likely be sufficient. Whereas if the user was seeking maximized muscle growth potential, then higher IGF-1 levels would be what they are after, and would then justify a higher dosing protocol. […] Hence, 50 mg is unnecessarily high to research with, and 25 mg is the benchmark for boosting IGF-1 levels significantly higher, while still reaping all of the benefits of the GH increase.”
Context: His reading of a study comparing 10 mg and 50 mg a day; the cut removes his summary of diminishing returns above 25 mg. Frequency is not stated in this passage.
“Here Is A Beginner’s MK-677 And CJC-1295 DAC Research Protocol: 2500mcg CJC-1295 DAC subQ inject before bed – Monday & Thursday (5000mcg – 5mg total per week) 25mg MK-677 before bed every day 200mcg HUPERZINE A taken 3x per day (600mcg total) […] For the record, this is the protocol I used myself when I used to use CJC-1295 DAC with my MK-677.”
Context: His own past protocol, combined with CJC-1295 DAC and huperzine A; he says he used it “when I was younger (and cared a lot more about getting as big as possible)”. The cut removes his estimate of the IGF-1 level reached. List items joined into one line.
“mk677 better known as IBU tomor 20 milligrams to 30 milligrams Orly once daily before bed”
Context: One line from a spoken cheat-sheet of growth-hormone secretagogues and the ranges he lists for them. “IBU tomor” and “Orly” are how the auto-captions render ibutamoren and orally; words are unchanged.
“I can't and will never recommend the use of a research chemical to anyone. But in the spirit of harm reduction, if you insist on trying it, you must be smart. Monitor your blood sugar, do your cardio, watch your blood pressure, keep the dose reasonable, with most research using anywhere from 10 to 25 milligs a day, and cycle it. Do not use this indefinitely.”
Context: He frames this as harm reduction, not a recommendation. The 10 to 25 range is what he says most research used. “milligs” is the caption wording for milligrams.
4 statements from 3 people about risks and how strong the evidence is.
“In terms of side effects, I have noticed some fairly significant lethargy from MK-677 (anything that raises GH and IGF-1 will do this), however, I was able to mitigate that to some extent by taking my daily dosage right before going to bed.”
Context: Elsewhere in the same review he says: “The incredibly heightened appetite is the main reason I avoid this compound now”.
“if you take it you have to be very controlled in the timeframe that you take it, like I wouldn’t recommend more than 62 possibly 12 weeks of a cycle with something like that. And then you have to go off of it for a while, because you’re going to change that receptor and it’s going to involute”
Context: He is warning that strong ghrelin-receptor drugs such as MK-677 can switch the receptor off, which he links to anxiety and low mood. “62” is how the published transcript renders it; the spoken words are probably “6 to”. He gives no dose.
“So, MK677 is going to be an F tier, mainly because you can't get a prescription MK677 anymore, and it raises growth hormone and IGF-1, which is great, but then drawbacks is it wrecks your hunger. It increases grein, which you're going to be hungry all the time. You're not going to be able to control your appetite. This is not good for most people. A lot of water retention, a lot of inflammation, and you can't control your glucose.”
Context: “grein” is how the transcript renders ghrelin. He gives no dose.
“It also raised fasting blood glucose by roughly 5 mg/dL and reduced insulin sensitivity. Appetite went up, as you would expect from agonizing the hunger receptor. Transient lower limb edema and muscle pain were the other common complaints.”
Context: His summary of the two-year Nass et al. (2008) trial; the 5 mg/dL is a blood-sugar change, not a dose.
Context, not a dosing guide. MK-677 has been tested in randomised trials, mostly in older adults, at 2–25 mg a day. These were medically supervised studies, so none of this establishes a dose for anyone else.
| Study | Studied in | What the study used | What it found |
|---|---|---|---|
| Chapman et al., 1996, J Clin Endocrinol MetabPubMed 8954023 | 32 healthy adults aged 64–81 | 2, 10 or 25 mg by mouth once daily for 2 and 4 weeks | GH and IGF-1 rose with dose; 25 mg/day raised 24-hour GH by 97% |
| Nass et al., 2008, Ann Intern MedPubMed 18981485 | 65 healthy adults aged 60–81, two years | 25 mg by mouth once daily vs placebo | Fat-free mass rose 1.1 kg vs a 0.5 kg fall on placebo; fasting glucose rose ~5 mg/dL and insulin sensitivity fell; no change in strength or function |
No. It is a small molecule taken by mouth. It is listed here because it is discussed alongside the growth-hormone-releasing peptides and acts on the same receptor.
Vigorous Steve’s range is “once daily before bed”, and Derek says taking it before bed reduced the lethargy he felt.
In the two-year trial: more appetite, mild swelling of the lower legs, muscle pain, higher fasting blood sugar and lower insulin sensitivity. Derek and Nicholas Trigili describe strong hunger.
We do not write our own dose ranges. The protocol cards show, word for word, what named people have publicly said, with their caveats and a link to the source.
Word-for-word statements about how MK-677 (ibutamoren) is used, including own-use reports, each with a link to the source. MK-677 is not a peptide: it is an oral small molecule that acts on the same ghrelin receptor as the GH-releasing peptides. The published trials are listed separately as context.
Last reviewed 11 Oct 2026 · Compiled by the Peptide Dosing editorial team · How we check quotes