Retatrutide

“Dose: 0.5mg. Timing: AM. Frequency: 3x per week. Duration: 8 weeks on, 8 weeks off (or until goal weight reached). Administration: SubQ injection. […] Jay’s Note: If you’ve used semaglutide or tirzepatide and want to understand what comes next — this is it. Start conservatively and respect the cycle structure.”

“It's probably safer to microdose retatrutide or the other GLP-1 receptor agonists, maybe three times weekly, Monday, Wednesday, Friday, at a low and effective dose, just enough to blunt your appetite, promote satiation, and take away the food noise when you're undergoing a cutting phase”

“Basically, the sustainable and tolerable dose really depends on how much appetite management you need during a cutting phase, and that could be between 0.25 mg up to 1.66 mg subcutaneous three times weekly, Monday, Wednesday, Friday, aka 0.75 mg to 5 mg weekly.”

“[…] which again is the commonly used dosage amongst the bodybuilders and everybody else in the fitness community nowadays. 3 mg retatrutide weekly split up 1 mg Monday, Wednesday, Friday, that seems to be the sweet spot for most people using this particular compound.”

“This is what's being discussed out there, presented so that you, the viewer, can understand the landscape, not so you can replicate it. The single biggest thing to understand is that the community doses retatrutide way lower than the trials did. Where the trials drove people to 4, 9, and 12 mg, the gray market crowd is mostly living around 2 to 4. The recurring pattern in user logs and forums looks like this. Start around 1 mg a week, with cautious ones at 1/2 mg, which is already half or less than the trial starting dose. Then, climb slowly, maybe half to a full mg every 2 to 4 weeks, by feel, rather than a fixed calendar. The reported sweet spot most people settle into is 2 to 4 mg a week, and plenty never go higher.”

“Now, the protocol that we use with patients starts anywhere between 1/2 to 1 mg. Maybe a bit more depending on certain circumstances and where they came from. 4 weeks at a half, then 1 mg for another 4 weeks, and then 2 mg. Where most clinics are starting people off from 2 mg on day number one.”

“I started my first retatrutide cycle around a half a milligram and every two weeks I started titrating my dose up. So I went from a half a milligram all the way up to four milligram even 6 milligram. From a half milligram I went to 2 milligram. That's where the best benefits actually showed up. My appetite came down but it was not zero. […] And this is the same pattern I'd seen with clients over and over and over. The best ones with the best results are the ones that actually stick to like the two to four milligram range. That's the range where you're actually still getting that metabolic and inflammatory benefits without completely destroying your ability to eat.”

“I followed that same principle though when I ran my own retatrutide experiment. I actually started much lower than the trials did. I started at a half a milligram and I eventually titrated up to 4 milligrams over the next six to seven weeks. […] You start at your lowest dose. You hold it for at least 2 weeks and you track your weekly loss. Now, if you're landing inside that 1 to 1.5% range and your side effects are still manageable, you do not touch that dose.”

“Let's say you peaked at 4 milligrams. You don't just stop cold, you taper. Weeks one and two, you drop from 4 milligrams down to 2 milligrams. Weeks three and four, you drop again to like 1 milligram. Week five, you drop to a half a milligram. That's roughly a six week taper from the decision that you decide to come off to your actual last injection.”