iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. Ipamorelin is not an approved medicine in the EU, UK or US. It is prohibited by WADA.
7 statements from 6 people. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.
“Ipamorelin dose: 200-300 mcg injected subcutaneously 1-3 times a day”
Context: Part of what he calls his upgraded version of Ben Greenfield’s “Wolverine” healing stack, for injuries. He writes that his business partner Nick Andrews used this protocol for a sprained knee.
“IP morelan 150 microgram to 300 microgr subcutaneously up to three times daily”
Context: One line from a spoken cheat-sheet listing several ghrelin-receptor agonists. Shortly before, he says “most people would use a growth hormone releasing hormone receptor agonist maybe once or twice per day in combination with a” ghrelin-receptor agonist. “IP morelan” and “microgr” are how the auto-captions render ipamorelin and microgram; words are unchanged.
“Dosing Guidelines: 100–500mcg 1–3x/day for a 12-week cycle; OR 10mL of 2000mcg/mL solution 1x/day, 5 days per week. Administration Route: Subcutaneous injection. Timing Tips: For muscle gain/fat loss, I’ve personally seen the best results using ipamorelin before bedtime on an empty stomach.”
Context: Published as “Dosing Guidelines” in his muscle gain/fat-loss stack; the timing tip is his own experience. Bullet points joined into one line.
“Taking advantage then of injecting something like Ipomerelin at bedtime […] the dosage of ipamorelin, and most of these growth hormone-related peptides, should be 100 micrograms. That's the max dose to bind the receptor. […] Ipamorelin, very clean. As long as you stay within 100 micrograms or less, people are going to lean out a little bit, sleep a little bit better.”
Context: “Ipomerelin” is the transcript’s spelling. The last part is from a few turns later; Huberman then says “They take it pre-sleep” and Koniver answers “Pre-sleep at bedtime.”
“Now you can inject these together always subcutaneously not interuscularly. And the best timing options are typically if you're going to use them both at the same time half that dose in the morning first thing in the morning when you get up half the dose right before bedtime. And the frequency, like I said, five days on, two days off. And the rest strategy, always try to take off two days in a row.”
Context: About CJC-1295 without DAC with ipamorelin. The per-injection figures he gives just before are captioned “1 to 200 micrograms” (CJC-1295) and “2 to 300 micrograms” (ipamorelin); we have held them for a listen. His later video (above) says to take both before bed. He says in his videos that he is not a doctor.
“The dosing for these peptides CJC-1295 sits at about 200 to 400 micrograms combined with ipamorelin about 100 micrograms to 300 micrograms subcutaneous injection taken together right before bed 5 days a week is the best entry point into GH optimization on it entire list.”
Context: From a fat-loss tier list; he does not say whether this is CJC-1295 with or without DAC. Caption spelling of the compound name corrected: “CJC25” → CJC-1295; “iMlan” → ipamorelin. He says in his videos that he is not a doctor.
“Many peptide clinics, including ours, use doses in the ballpark of, say, 100 micrograms of CJC 1295 and upwards of 150 to 250 micrograms of Ipamorelin. This can vary based off your goals and your response, but that's the ballpark most people start. You don't boost up the CJC. You have a saturation level of about 100 micrograms of CJC. But, the Ipamorelin, you can go up to probably 250, 300 before you get to that saturation point if you really want to improve the results. Cycling. A common protocol, 5 days on, 2 days off”
Context: The two are used together. He does not say whether the CJC-1295 is the version with or without DAC. Just before this he says a second daily dose would go first thing in the morning, fasted.
6 statements from 3 people about risks and how strong the evidence is.
“Ipamorelin is in this category two. So, it's definitely going to increase ghrelin, which is going to increase hunger.”
Context: “Category two” is his label for ghrelin-mimetic secretagogues.
“It also tends to really improve sleep, but again, by increasing the amount of deep sleep. We don't know whether or not it does that […] at the expense of rapid eye movement sleep.”
Context: The omission removes a slip in the captions (“does that to at the expense”).
“While I'm not opposed to that approach, you just want to make sure that the dosing, or I should say the relative dosing of each peptide is such that, you know, you're avoiding unnecessary increases in prolactin and cortisol, and that you're not hitting a pathway redundantly.”
Context: Said about people who combine ipamorelin with CJC-1295.
“If you're younger than 30, I don't know why you'd want to augment growth hormone unless you and your doctor decide that there's a clinical need or some other urgent need to do so because you're already making a lot of growth hormone. If you're older than 30 and you're interested in using these compounds, to me it stands to reason that of course you want to make sure that you don't have any tumors or cancers that you could potentially exacerbate. But in addition to that, that you really think about using the minimal effective dose and that you use perhaps even the mildest of these different compounds […]”
Context: Said in his closing summary on growth-hormone secretagogues as a group (sermorelin, tesamorelin, CJC-1295, ipamorelin and others), not about this compound alone.
“What I've seen is, with ipamorelin, rare, but some people do get anaphylaxis, and it's happened. I think that happens when people are pushing it and giving more than they should. I've heard of that. They're giving 200, 300, 400 micrograms at a time, which is a big dose.”
Context: His own observation, not a study result. He goes on to describe flushing that people mistake for the peptide “working”.
“I've done arduous calculations from the literature on exactly how much growth hormone you actually get out of let's say 125 micrograms of iper morelan yeah and um it was quite I wouldn't say shocking but for 125 micrograms at hper morelan on average it's between .5 to7 I of grow hormon secreted”
Context: Steve asks “Dean Dean what do you think” about GH secretagogues just before. “iper morelan” is ipamorelin; “.5 to7 I of grow hormon” means 0.5 to 0.7 IU of growth hormone. This is his calculation from studies, not a dose recommendation.
Context, not a dosing guide. These are the conditions reported in published studies. The human trials used intravenous dosing in hospital or research settings, which does not translate to self-injection. None establishes a safe or effective dose for healthy people.
| Study | Studied in | What the study used | What it found |
|---|---|---|---|
| Gobburu et al., 1999, Pharm ResPubMed 10496658 | Healthy men | Intravenous infusions at several dose levels | Half-life about 2 hours; a single GH peak at about 0.67 h |
| Beck et al., 2014, Int J Colorectal DisPubMed 25331030 | 114 patients after bowel surgery (phase 2) | 0.03 mg/kg IV twice daily for up to 7 days | Well tolerated; no significant difference from placebo in gut recovery |
| Study | Studied in | What the study used | What it found |
|---|---|---|---|
| Raun et al., 1998, Eur J EndocrinolPubMed 9849822 | Rats and pigs | Various IV doses | Selective GH release without the ACTH/cortisol rise seen with other GHRPs |
No. It reached phase 2 trials for post-operative ileus but was not approved anywhere.
The two act on different receptors (ghrelin receptor and GHRH receptor). Huberman’s caution about combining them is quoted above.
It acts on the ghrelin receptor; Huberman says it will increase hunger. See the safety quotes.
We do not write our own dose ranges. The protocol cards show what named people have publicly said, with a link to the source.
Word-for-word statements about how ipamorelin is used and what to watch for, each with a link to the source. The published research is listed separately as context.
Last reviewed 11 Oct 2026 · Compiled by the Peptide Dosing editorial team · How we check quotes