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Kisspeptin-10

A hormone signal that switches on testosterone and fertility hormones.

StatusInvestigational; not approved (EU/UK/US); WADA prohibited in men
How well studied in peopleSmall human studies
Experts quoted3 experts

iNot medical advice. We don’t recommend any dose. Every dose below is a quote from the person named, describing their views or their own use. Kisspeptin-10 is a research peptide, not an approved medicine in the EU, UK or US. WADA prohibits kisspeptin and its agonist analogues in men (S2.2.1).

What experts say about dosing

2 statements from 2 people. Each one is word for word: we add punctuation only and mark cuts with […]. The chips repeat the exact words used.

Vigorous SteveBodybuilding coach and YouTuber (VigorousSteve)

Own use: 100 mcg experiment

Dose
“100 micrograms”
How often
“three times per week, then every day”
How long
“two weeks … another two weeks”
Also said
“no changes in LH, FSH or testosterone”

“after two weeks on 100 micrograms kisspeptin 10 three times per week they did not increase […] so I increased to 100 microgram kisspeptin 10 every day, ran that experiment for another two weeks and see if there was any changes, again no changes”

Watch at 11:15Individual PED Risk Vs. Reward Assessment & Management | GHK-Cu & Kisspeptin-10 Update (VigorousSteve) · 27 Jun 2021

Context: Describing his own blood-work experiment while off steroids. He started from the protocol of “the people that I had a consultation with”. Measured LH, FSH and testosterone did not change. The cut removes his description of the blood panel.

Jay CampbellAuthor and podcaster on hormones and peptides; co-founder of a peptide company

Before bed, 30 days on and off

Dose
“125mcg”
How often
“Every day”
How long
“30 days on, 30 days off”
How taken
“SubQ injection”
When
“1 hour before bed”

“Dose: 125mcg. Timing: 1 hour before bed. Frequency: Every day. Duration: 30 days on, 30 days off. Administration: SubQ injection. […] Jay’s Note: Running it before bed aligns with the body’s natural LH pulse rhythm — and you’ll feel the difference in morning testosterone and libido within the first two weeks.”

Read the sourceJay Campbell’s Muscle Building Protocol (jaycampbell.com) · 21 Apr 2026

Context: The card says “Kisspeptin” without naming the form. Quoted from a protocol card on his website (the field labels Dose, Timing, Frequency, Duration and Administration are his). The protocol pages say every protocol has been “personally tested, refined, and used by Jay Campbell”, and most cards link to a product from BioLongevity Labs, a company he co-founded.

What experts say about safety

2 statements from 2 people about risks and how strong the evidence is.

Vigorous SteveBodybuilding coach and YouTuber (VigorousSteve)

Dosing used in studies

“they administer 20 micrograms every two hours, which, let's be honest, is incredibly cumbersome. I can't remember if that was intervenous, subcutaneous or intramuscularly”

Watch at 12:15Individual PED Risk Vs. Reward Assessment & Management | GHK-Cu & Kisspeptin-10 Update (VigorousSteve) · 27 Jun 2021

Context: His summary of the research protocol, explaining why he thinks his own experiment showed no effect.

Andrew HubermanNeuroscientist, Stanford School of Medicine; host of Huberman Lab

Libido use is a wild card

“the use of kisspeptin to increase vitality and libido is a bit of a um let's just say it's a it's a little bit of a wild card. We don't yet know all the effects of kisspeptin.”

Watch at 1:21:31Huberman Lab: Benefits & Risks of Peptide Therapeutics for Physical & Mental Health · 1 Apr 2024 · show notes

Context: Earlier he notes that synthetic kisspeptin is “prescribed for what's called hypothalamic amenorrhea”. He gives no dose.

Go deeper

What the research used

Context, not a dosing guide. These human studies were short, used intravenous infusions or repeated injections in hospital settings, and measured hormone levels rather than fertility or libido outcomes. They are evidence context, not a guide.

Human studies

StudyStudied inWhat the study usedWhat it found
George et al., 2011, J Clin Endocrinol MetabPubMed 21632807Healthy menKisspeptin-10 IV bolus 0.01–3 µg/kg; infusions of 1.5 or 4 µg/kg/hLH rose, peaking at 1 µg/kg (less at 3 µg/kg); infusion raised LH and testosterone
Dhillo et al., 2005, J Clin Endocrinol MetabPubMed 16174713Healthy menKisspeptin-54 infusion (a longer form)LH, FSH and testosterone rose; half-life about 28 minutes
Jayasena et al., 2009, J Clin Endocrinol MetabPubMed 19820030Women with hypothalamic amenorrhoeaKisspeptin-54 twice-daily subcutaneous injections for 2 weeksStrong LH/FSH response on day 1, much reduced by day 14 (desensitisation)
What we don’t know yet
  • Studies measure short-term hormone levels, not fertility or libido.
  • Repeated dosing can cause desensitisation (Jayasena 2009).
  • Kisspeptin-10 has a very short half-life, which is why studies used infusions.
  • Grey-market products are unregulated, so identity, purity and dose accuracy vary.
Common questions

Did kisspeptin-10 raise hormones in Vigorous Steve’s experiment?

He reports that 100 micrograms three times per week, then daily, did not change his LH, FSH or testosterone. See his quotes.

Is kisspeptin approved for anything?

It is not a marketed medicine in the EU, UK or US. Huberman says synthetic kisspeptin is prescribed for hypothalamic amenorrhoea; see his context note.

Is kisspeptin allowed in sport?

No. WADA prohibits kisspeptin and its agonist analogues in men (S2.2.1).

Why does the protocol section only contain quotes?

We do not write our own dose ranges. The protocol cards show, word for word, what named people have publicly said, with their caveats and a link to the source.

About this page

Word-for-word statements about kisspeptin-10 for the hormone axis, including an own-use experiment, each with a link to the source. The research is listed separately as context.

Also known as
Metastin 45-54; KP-10
Type
Fragment of the kisspeptin hormone (10 amino acids)
Last updated
11 Oct 2026

Last reviewed 11 Oct 2026 · Compiled by the Peptide Dosing editorial team · How we check quotes