Comparison
Two GHRH analogues: an older one and one approved for HIV-related belly fat. Below, each one is shown with its status, the state of the human evidence and what named experts have said, word for word.
iNot medical advice. We don’t recommend any peptide or dose, and this page does not say which one is “better”. Every dose below is a quote from the person named.
| Sermorelin | Tesamorelin | |
|---|---|---|
| What it is | An older medicine that prompts natural growth-hormone release. | A medicine for belly fat in people with HIV; discussed for visceral fat. |
| Category | Growth hormone boosters | Growth hormone boosters |
| Status | Formerly FDA-approved (Geref, withdrawn 2009 for non-safety reasons); not EU-authorised; WADA prohibited | FDA-approved 2010 (HIV-associated abdominal fat); not EU-authorised; WADA prohibited |
| How well studied in people | Approved medicine | Approved medicine |
| Experts quoted | 5 | 7 |
| Dose statements | 5 | 10 |
Statements filed under one of them that also mention the other.
“Tesamorelin is a bit more long-lasting than sermorelin and therefore is taken typically about three times per week, not five times per week.”
Context: Descriptive, comparing it with sermorelin. He gives no tesamorelin dose.
One statement per expert (the earliest), out of 5 statements on the full page. Quotes are word for word, with cuts marked […].
“By the way, the typical dosages of sermorelin that are um taken are anywhere from 200 to 400 micrograms. Typically, that's done at night before sleep for the reasons that we talked about before. And typically, people will take it anywhere from three times per week or five times per week. There are some disadvantages to taking it continuously 7 days per week for long periods of time. There's some desensitization that can occur. Not much, but some can occur.”
Context: Descriptive (“typical dosages … that are taken”), not a recommendation. “The reasons we talked about” refers to growth hormone being released mainly in early sleep.
“so somorin is a ghrh analog right so again it mimics what we do in the brain and the dosing for somorin is 500 micrograms twice a day 5 days on two days off”
Context: “somorin” is how the captions render sermorelin (he lists “soral Tessa moral in CJC 1295 and IAM moral in” just before).
“Then sermorelin has actually a very broad dosing range anywhere from 200 micrograms. I've used it up to 3,000 micrograms-”
Context: The sentence is cut off in the transcript where Huberman reacts (“Whoa.”). How often is not stated.
“Sermorelin, you could start with anywhere between 250 to 500 micrograms daily. I've had guys go up to 1 milligram daily. […] You can inject them together subcutaneously. Now timing I always stick with something very similar just like I mentioned earlier with the five days on two days off approach.”
Context: “Them” is sermorelin with tesamorelin. The cut removes his tesamorelin figure (500 micrograms to 1 milligram daily). Caption spelling of the compound name corrected: “Samorin” → Sermorelin. He says in his videos that he is not a doctor.
One statement per expert (the earliest), out of 10 statements on the full page. Quotes are word for word, with cuts marked […].
“Tesamorelin dose: 1 mg right before bed yet 90 minutes after your last meal, and 1 mg upon waking yet ideally before exercise (via subcutaneous injection)”
Context: Part of the same injury stack. On his 2026 muscle-building protocol page he writes: “Tesamorelin is my go-to for elevating GH output”.
“and tesamorelin 1 milligram to 2 milligram subcutaneous up to three times daily”
Context: One line of his spoken GH cheat-sheet. He follows it with “that being said most people would use a growth hormone releasing hormone receptor agonist maybe once or twice per day in combination with a” ghrelin-receptor agonist.
“Tesamorelin is a bit more long-lasting than sermorelin and therefore is taken typically about three times per week, not five times per week.”
Context: Descriptive, comparing it with sermorelin. He gives no tesamorelin dose.
“Dosing Guidelines: 1mg 1–2x/day for 5 days per week for a 6–8 week cycle; OR 5mL of 1mg/0.6mL solution 1x/day, 6 days per week for a 6–8 week cycle. Administration Route: Subcutaneous injection. Timing Tips: Before bed, take it at least 90 minutes after eating. Upon waking, take tesamorelin ideally before exercise and eating.”
Context: Published as “Dosing Guidelines” in his recovery stack. Bullet points joined into one line.
“The two that are different would be tesamorelin, ideal dose 2 milligrams per dose, which is 2,000 micrograms, so quite different.”
Context: Contrasting it with the 100 microgram amount he gives for ipamorelin, GHRP-6 and hexarelin. How often is not stated here. Elsewhere in the episode he describes a bedtime stack of BPC-157, ipamorelin and tesamorelin used with patients.
“Now, my experiments, don't copy these. I've used tesamorelin up to 2 milligrams a day, four to five to six times a week, never every day with these peptides. And I'm going to use this peptide for 16 to 30 to 40 weeks”
Context: Part of a visceral-fat stack with CJC-1295, ipamorelin, MOTS-c and retatrutide; he says he adds tesamorelin around week 16–24. Caption spelling of the compound name corrected: “Tesmearellin” → tesamorelin. He says in his videos that he is not a doctor.
“the FDA-labeled dose is around 1 to 2 mg daily. But, that 2 mg, I've never seen anybody take that off-label. In our clinic, we use different dosing and often a cycling schedule. Timing matters. We have patients take it away from meals, often in the evenings. Food, especially carbohydrates, will blunt the growth hormone release. So, an empty stomach helps maximize the goals. Think 1 mg at the most. 500 micrograms to 1,000 micrograms, 5 days on, 2 days off before bed.”
Context: What he says his clinic uses. In another video (N8fjEY1w45c, 8:03) he says the clinic gets results “with usually about a milligram, 1,000 micrograms”.
These are the conditions reported in published studies, mostly in children with GH deficiency or small groups of older adults. None establishes a dose for healthy adults.
See the studies on the Sermorelin page
These are the conditions in published trials, all in people with HIV. They show what was tested for a specific medical use, not a dose for anyone else.
Compiled from the quotes and research already on each peptide page. Last updated 11 Oct 2026. More comparisons · Glossary