Comparison
Two ways of prompting the body’s own growth-hormone release. Below, each one is shown with its status, the state of the human evidence and what named experts have said, word for word.
iNot medical advice. We don’t recommend any peptide or dose, and this page does not say which one is “better”. Every dose below is a quote from the person named.
| Ipamorelin | Sermorelin | |
|---|---|---|
| What it is | Nudges the body to release more of its own growth hormone. | An older medicine that prompts natural growth-hormone release. |
| Category | Growth hormone boosters | Growth hormone boosters |
| Status | Not approved (EU/UK/US); WADA prohibited | Formerly FDA-approved (Geref, withdrawn 2009 for non-safety reasons); not EU-authorised; WADA prohibited |
| How well studied in people | Tested in clinical trials | Approved medicine |
| Experts quoted | 8 | 5 |
| Dose statements | 7 | 5 |
Statements filed under one of them that also mention the other.
No checked quote mentions them together yet.
One statement per expert (the earliest), out of 7 statements on the full page. Quotes are word for word, with cuts marked […].
“Ipamorelin dose: 200-300 mcg injected subcutaneously 1-3 times a day”
Context: Part of what he calls his upgraded version of Ben Greenfield’s “Wolverine” healing stack, for injuries. He writes that his business partner Nick Andrews used this protocol for a sprained knee.
“IP morelan 150 microgram to 300 microgr subcutaneously up to three times daily”
Context: One line from a spoken cheat-sheet listing several ghrelin-receptor agonists. Shortly before, he says “most people would use a growth hormone releasing hormone receptor agonist maybe once or twice per day in combination with a” ghrelin-receptor agonist. “IP morelan” and “microgr” are how the auto-captions render ipamorelin and microgram; words are unchanged.
“Dosing Guidelines: 100–500mcg 1–3x/day for a 12-week cycle; OR 10mL of 2000mcg/mL solution 1x/day, 5 days per week. Administration Route: Subcutaneous injection. Timing Tips: For muscle gain/fat loss, I’ve personally seen the best results using ipamorelin before bedtime on an empty stomach.”
Context: Published as “Dosing Guidelines” in his muscle gain/fat-loss stack; the timing tip is his own experience. Bullet points joined into one line.
“Taking advantage then of injecting something like Ipomerelin at bedtime […] the dosage of ipamorelin, and most of these growth hormone-related peptides, should be 100 micrograms. That's the max dose to bind the receptor. […] Ipamorelin, very clean. As long as you stay within 100 micrograms or less, people are going to lean out a little bit, sleep a little bit better.”
Context: “Ipomerelin” is the transcript’s spelling. The last part is from a few turns later; Huberman then says “They take it pre-sleep” and Koniver answers “Pre-sleep at bedtime.”
“Now you can inject these together always subcutaneously not interuscularly. And the best timing options are typically if you're going to use them both at the same time half that dose in the morning first thing in the morning when you get up half the dose right before bedtime. And the frequency, like I said, five days on, two days off. And the rest strategy, always try to take off two days in a row.”
Context: About CJC-1295 without DAC with ipamorelin. The per-injection figures he gives just before are captioned “1 to 200 micrograms” (CJC-1295) and “2 to 300 micrograms” (ipamorelin); we have held them for a listen. His later video (above) says to take both before bed. He says in his videos that he is not a doctor.
“Many peptide clinics, including ours, use doses in the ballpark of, say, 100 micrograms of CJC 1295 and upwards of 150 to 250 micrograms of Ipamorelin. This can vary based off your goals and your response, but that's the ballpark most people start. You don't boost up the CJC. You have a saturation level of about 100 micrograms of CJC. But, the Ipamorelin, you can go up to probably 250, 300 before you get to that saturation point if you really want to improve the results. Cycling. A common protocol, 5 days on, 2 days off”
Context: The two are used together. He does not say whether the CJC-1295 is the version with or without DAC. Just before this he says a second daily dose would go first thing in the morning, fasted.
One statement per expert (the earliest), out of 5 statements on the full page. Quotes are word for word, with cuts marked […].
“By the way, the typical dosages of sermorelin that are um taken are anywhere from 200 to 400 micrograms. Typically, that's done at night before sleep for the reasons that we talked about before. And typically, people will take it anywhere from three times per week or five times per week. There are some disadvantages to taking it continuously 7 days per week for long periods of time. There's some desensitization that can occur. Not much, but some can occur.”
Context: Descriptive (“typical dosages … that are taken”), not a recommendation. “The reasons we talked about” refers to growth hormone being released mainly in early sleep.
“so somorin is a ghrh analog right so again it mimics what we do in the brain and the dosing for somorin is 500 micrograms twice a day 5 days on two days off”
Context: “somorin” is how the captions render sermorelin (he lists “soral Tessa moral in CJC 1295 and IAM moral in” just before).
“Then sermorelin has actually a very broad dosing range anywhere from 200 micrograms. I've used it up to 3,000 micrograms-”
Context: The sentence is cut off in the transcript where Huberman reacts (“Whoa.”). How often is not stated.
“Sermorelin, you could start with anywhere between 250 to 500 micrograms daily. I've had guys go up to 1 milligram daily. […] You can inject them together subcutaneously. Now timing I always stick with something very similar just like I mentioned earlier with the five days on two days off approach.”
Context: “Them” is sermorelin with tesamorelin. The cut removes his tesamorelin figure (500 micrograms to 1 milligram daily). Caption spelling of the compound name corrected: “Samorin” → Sermorelin. He says in his videos that he is not a doctor.
These are the conditions reported in published studies. The human trials used intravenous dosing in hospital or research settings, which does not translate to self-injection. None establishes a safe or effective dose for healthy people.
See the studies on the Ipamorelin page
These are the conditions reported in published studies, mostly in children with GH deficiency or small groups of older adults. None establishes a dose for healthy adults.
Compiled from the quotes and research already on each peptide page. Last updated 11 Oct 2026. More comparisons · Glossary