MOTS-c vs SS-31 (elamipretide)

“And SS-31, 5 to 10 mg per week, dose the same exact way. If I'm cycling together though, I start SS-31 by itself for the first two to four weeks to repair the machine. Then, you can layer MOTS-c on top of that.”

“So, here's how I would actually sequence this. I would start with SS-31 on its own. I would start with 2 mg five times per week for four weeks before I would start MOTS-c. Now, you can technically go two to four weeks.”

“The way I like to run MOTS-c is running it like this. I take 5 to 10 milligrams subq subcutaneously two to three times per week. Most people do well starting at 5 millig three times a week and adjusting it from there”

“They want to control, and moderate that metabolism, so everything is functioning at its highest, and they want to improve their exercise capacity of the cell. Then that’s basically something where you would use 10 milligrams, and you’d use it once a week if we have, and that’s a subcutaneous injection, and what you need to know about MOTS-c. It is very fragile. It needs to be kept in a dark space in a refrigerator. And once you reconstitute it, you’ve got four hours to use it or less or it’s no good anymore.”

“I, I, I do it intermittently […] you can do the protocols 10 milligrams once a week or 5 milligrams sub Q twice a week, um, you could go a little further if you have an event, like you're, you're, you're trying to like, yeah, run faster, like you have a marathon coming up or something like that, but in general just, uh, once to two times a week”

“Dosing Guidelines: 10mg 1x/week for 10 weeks, 1x/year. Administration Route: Subcutaneous injection. Timing Tips: For added mitochondrial benefit, administer MOTS-c right before endurance exercise, ideally in the morning.”

“So for those people and for most people I would suggest just to start low, start with subcutaneous administrations and build your ways up. If you go with 10 milligrams intramuscularly, it's probably not going to end well for you. […] So, um, I circumvent that by doing daily micro administrations of modsi subcutaneously.”

“Dose: 1 mg. Timing: AM. Frequency: 5 days on, 2 days off. Duration: 8 weeks on, 8 weeks off. Administration: SubQ injection. […] Jay’s Note: MOTS-C is unlike anything else in this stack — it originates from within the mitochondria. The research on AMPK activation and metabolic regulation here is some of the most compelling I’ve seen. Run it fasted in the AM.”

“That said, here's what people are doing. The most recent circulating protocols for MOTS-c is somewhere between 5 and 15 mg injected subcutaneously three times a week for 8 to 12 weeks, followed by 4 to 8 weeks off. […] Now, I have seen more aggressive protocols where people are running 1 to 3 mg daily, but biohacker forums are full of variations.”

“The protocol that our medical team uses is 10 mg in a single injection once a week. Morning administration. This is what I see working. If you want to load in faster, you can hit a saturation point. Some patients will run it up to three times per week just for two weeks. Same 10 mg dose, but three times a week. After that, back to once a week. 8 weeks to 12 is a maximum cycle before you take a break, say a month or two off.”

“SS-31 is typically dosed like this. I would start with 3 to 5 milligrams subq once a day. I like that my clients inject it first thing in the morning so it becomes part of their routine. they don't forget about it and they run it for a full length of your retatrutide cycle.”

“I do like you have done um five milligrams five days per week for three weeks in a row but that's with everything else in play like Moy SLU metal that did I notice a massive benefit I can't really say”

“That's 40 milligrams every single day. That's the problem resolving dose. Um, I ran 10 milligrams per day to see if it would improve kidney markers. It did not. I use 2 milligrams right now. I, I don't notice a difference anywhere between 1 millig to 10 milligrams.”

“SS-31 (Elamipretide): 2-8 mg 3 times a week in every-other-day fashion for the next four weeks, with weekends being used as a break. […] As indicated, do not run any of these agents for more than one month straight.”

“none of this is me writing you a prescription. […] Every pivotal human trial dosed this at 40 mg a day. The gray market crowd, mostly because this stuff is expensive, is mostly running at somewhere between 2 and 10. So, when you see all those I tried SS-31 and felt nothing reports, that isn't necessarily the drug failing you. It might be a quarter of the dose that also did nothing in the formal trial.”